1st CSSB International Symposium

Systems in Infection Biology
From Molecules to Organisms

Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany

Thursday 9 April - Saturday 11 April 2015

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Final Programme

Day 1- Thursday 09 April 2015
TimeSpeaker
Session 1: Areas in infection biology requiring system biology approaches
09:00-12:00
Chair: Martin Hällberg
09:00h Welcome Address
09:30h Session Introduction
Martin Hällberg, CSSB / Karolinska Institutet, Stockholm, Sweden
09:35h Salmonella diarrhea: in need for systems biology approaches for each step of the disease
Wolf-Dietrich Hardt, ETH Zürich, Switzerland
10:05h Mapping and Modeling of Microbial Cellular Networks
James Galagan, Boston University, Boston, USA
10:35h COFFEE BREAK
11:00h

Dual RNA-seq unveils noncoding RNA functions in Salmonella-host interplay
Jörg Vogel, IMIB - Institute for Molecular Infection Biology, Würzburg, Germany

11:30h

Dissection of the translocation events during protein export in blood stages of the human malaria parasite Plasmodium falciparum
Paolo Mesen Ramirez, Bernhard Nocht Institute for Tropical Medicine, Germany

11:45h

Investigation of the mode of action of the protein VapA of Rhodococcus equi on phagosome membranes
Christian Nehls, Research Center Borstel, Germany

12:00h

Identification of proteins involved in the uptake of host cell cytosol in blood stages of the human malaria parasite Plasmodium falciparum
Sven Flemming, Bernhard Nocht Institute for Tropical Medicine, Germany

12:15h LUNCH BREAK
Session 2: "Omics" in infection biology
14:00-17:15

Chair: Tim Gilberger
14:00h

Session Introduction
Tim Gilberger, CSSB / Bernhard-Nocht-Insitute for Tropical Medicine / Universität Hamburg, Hamburg, Germany

14:05h

Antibiotic adjuvants: A systems biology strategy to rescue legacy drugs
Gerry Wright, McMaster University, Hamilton, Canada

14:35h Comparative Systems Biology of the Apicomplexa
John Parkinson, University of Toronto, Canada
15:05h Covariation of pathogen and host in infection
Deborah Hung, Broad Institute, Cambridge, USA
15:35h COFFEE BREAK
16:00h Panorama of ancient metazoan macromolecular complexes
Andrew Emili, Univeristy of Toronto, Canada
16:30h

High throughput identification of microRNAs modulating infection by bacterial pathogens
Ana Eulalio, Institute for Molecular Infection Biology, University of Wuerzburg, Germany

16:45h

An integrative approach for discovery and structural study of large protein complexes from a thermophilic eukaryote
Francis O'Reilly, EMBL Heidelberg, Germany

17:15h DEPARTURE OF COACHES FOR DESY
18:15h PARTIAL DESY TOUR
19:45h SYMPOSIUM DINNER - DESY Canteen
Day 2 - Friday 10 April 2015
TimeSpeaker
Session 3a: Modeling of experimental Omics data
09:00-10:35
Chair: Vitor Martins dos Santos
09:00h Session Introduction
Vitor Martins dos Santos, Wageningen University, Wageningen, Netherlands
09:05h The systems biology of apoptosis: from single-cell imaging to computational modelling to clinical applications - an unexpected journey
Jochen Prehn, Royal College of Sugeons in Ireland, Dublin, Ireland
09:35h Computational Modeling of Host-Pathogen Interactions
Edda Klipp, HU Berlin, Germany
10:05h

Crystal structure of the V(D)J recombinase RAG1 RAG2
Mikalai Lapkouski, CSSB Karolinska Institutet, DESY, Germany

10:20h

Understanding Oxygenase Recruitment in Glycopeptide Antibiotic Biosynthesis
Max Cryle, MPI for Medical Research, Germany

10:35h COFFEE BREAK
Session 3b: Biotechnical Applications of Systems Biology
11:00-12:35
Chair: An-Ping Zeng
11:00h Session Introduction
An-Ping Zeng, Technical University Hamburg-Harburg, Hamburg, Germany
11:05h Mathematical modeling and computational analysis in Metabolic Engineering
Andreas Kremling, Technical University Munich, Germany
11:35h Streamlining and Reprogramming Microbes for Industrial Applications
Vitor Martins dos Santos, Wageningen University, Wageningen, The Netherlands
12:05h Computational Approaches to Active Site Analysis
Matthias Rarey, University of Hamburg, Germany
12:20h

Fighting biofilms of Streptococci by a novel inhibitor and a systems biology approach
Irene Wagner Döbler, TU Hamburg Harburg, Germany
(Presenter:
An-Ping Zeng, Technical University Hamburg-Harburg, Hamburg, Germany)

12:35h LUNCH BREAK
Session 4: Structural biology as a "high end" method in systems biology
14:00-17:00

Chair: Kay Grünewald
14:00h Session Introduction
Kay Grünewald, University of Oxford/CSSB/Heinrich Pette Institute/Universität Hamburg
14:05h Integrated structural biology of genome transcription
Patrick Cramer, Max Planck Institute for Biophysical Chemistry , Göttingen, Germany
14:35h

Structural Systems Pharmacology: the role of 3D structures in next generation drug development
Patrick Aloy, Institute for Research in Biomedicine, Barcelona, Spain

15:05h Fitting and Assessment of Atomic Models in 3D Electron Microscopy Maps of Macromolecular Assemblies
Maya Topf, University of London, UK
15:35h COFFEE BREAK
16:05h Studying viral assemblies with mass spectrometry and XFELs
Charlotte Uetrecht, Heinrich Pette Institute/European XFEL Facility GmbH, Germany
16:20h

Serial crystallography using advanced light sources: pushing the limits
Cornelius Gati, Deutsches Elektronensynchrotron, Germany

16:35h

Crystal Structure of the Dynamin Tetramer
Susanne Eschenburg, Hannover Medical School, Germany

17:00h POSTER SESSION
with fingerfood buffet
Day 3 - Saturday 11 April 2015
TimeSpeaker
Session 5: Protein-Ligand interactions "at all levels"
09:00-11:15
Chair: Anne-Claude Gavin
09:00h Session Introduction
Anne-Claude Gavin, European Molecular Biology Laboratory, Heidelberg, Germany
09:05h Design of protein interactions to characterize existing and engineer new functions
Tanja Kortemme, University of California, San Francisco, USA
09:35h Lipid protein interactions
Anne-Claude Gavin, European Molecular Biology Laboratory, Heidelberg, Germany
10:05h

From Micro to Nano   Structure of Interacting Cellular Surfaces
Christian Voigt, University of Hamburg, Germany

10:20h

Structural investigation of co assembled clathrin adaptor protein complexes by native mass spectrometry
Johannes Heidemann, Heinrich Pette Institute, Germany

10:35h

Interaction Between Host Defence Peptides and Mycobacteria
Thomas Gutsmann, Research Center Borstel, Germany

10:50h COFFEE BREAK
Session 6 (Panel Discussion): What's next? Functional follow-up questions
11:15-12:45
Chair: Thomas Marlovits
Panel: James Galagan, Wolf-Dietrich Hardt, Edda Klipp, Thomas Marlovits, Joel Sussman
11:15h Concluding Disussion
12:45h Closing remarks and Poster Prize
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